Table 3.

Number of leave-one-out mispredictions when classifying an organism into two temperature optimum ranges, hyperthermophile versus non-hyperthermophile (hyper vs. non-hyper) and mesophile versus non-mesophile (meso vs. non-meso) using all tetramers frequencies over the entire vitrual coding strand, based on a model from the genomes of the other 194 organisms. The leave-one-out classifications were made for the 195 original genomes (original) and two types of randomly generated control sequences, multinomial (multi) and Markov.

Temperature range	Original	Random control
		Multi	Markov
Hyper vs. non-hyper	8 (4.1%)	16 (8.2%)	8 (4.1%)
Meso vs. non-meso	14 (7.2%)	59 (30.3%)	21 (10.8%)