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. 2009 May 29;284(22):15173–15183. doi: 10.1074/jbc.M900322200

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Copyright © 2009, The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 5. — Induction of light-induced acute retinal degeneration in 9-cis-retinyl acetate-gavaged Lrat^-/-Rdh8^-/-Abca4^-/- mice. A, 6-week-old Lrat^-/-Rdh8^-/-Abca4^-/- and Lrat^-/- mice were gavaged once with 2 mg of 9-cis-retinyl acetate (9cRAc) and kept in the dark for 3 days. Then mice were illuminated with light at an intensity of 10,000 lux. After 7 days of dark adaptation, retinal morphology was viewed after DAPI staining of cryosections. Representative images are shown (n > 5). B, incidence of light-induced retinal degeneration (numbers of mice with retinal degeneration/total numbers of tested animals) is shown for Lrat^-/-Rdh8^-/- Abca4^-/- mice receiving 1 or 3 cycles of gavage with 2 mg of 9-cis-retinyl acetate followed by 3 days of dark adaptation and then a 24-min exposure to bright light (intensity 500 cd·m^-2).