TABLE 1.

50% inhibitory concentration (IC₅₀) of selected PP1 analogs for Pto^as kinase activity

Inhibition assays were carried out by testing GST-Pti1 (K96N) phosphorylation by GST-Pto^as in the presence of various inhibitor concentrations ranging from 1 nm to 1 μm.

Inhibitor	IC50a
	nm
1NM-PP1	120
3MB-PP1	160
2Na-PP1	250
Ac-PP1	350

^aIC₅₀ is defined as the concentration of the inhibitor at which Pto^as kinase activity was 50% of the control (no inhibitor).