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. 2009 Apr 10;5(4):e1000350. doi: 10.1371/journal.pcbi.1000350

Figure 3. Correlation between information flow scores and loss-of-function phenotypes.

Figure 3

The higher a protein's information flow score is, the higher the probability of observing lethality (Panel A) or pleiotropy (Panel B) when the protein is deleted from S. cerevisiae. This trend is observed for C. elegans as well (Panel C and Panel D). The correlation is not as strong for betweenness and loss-of function phenotypes. The PCCs for information flow scores and phenotypes are 0.84, 0.60, 0.95, and 0.85 in Panels A–D, respectively. In contrast, the PCCs for betweenness and phenotypes are −0.02, −0.31, 0.67, and 0.49 in Panels A–D, respectively.