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. 2009 Apr 10;5(4):e1000350. doi: 10.1371/journal.pcbi.1000350

Figure 4. Correlation between information flow scores and loss-of-function phenotypes among proteins of low betweenness.

Figure 4

Even among those proteins that rank in the lower 30% in terms of betweenness, a protein's information flow score is still a good indicator for the probability of observing lethality (Panel A) or pleiotropy (Panel B) when the protein is deleted from S. cerevisiae. This trend is observed for C. elegans as well (Panel C and Panel D). The PCCs for information flow scores and phenotypes are 0.89, 0.79, 0.69, and 0.65 in Panels A–D, respectively.