Table 1.
SNPs from the current study showing replication with GWAS hits
| Phenotype | Previous GWAS hit (alternate phenotype previously showing association) | rs | Gene | P-value | FDR | Common versus rare HMZ | % R2trans | MAF |
|---|---|---|---|---|---|---|---|---|
| Triglycerides | (6)(LDL) | rs6589566 | APOA5-A4-C3-A1 | 1.98E−05 | 0.01 | 0.633 | 0.9 | 7.0 |
| (15) | rs328 | LPL | 2.85E−04 | 0.03 | 0.189 | 0.7 | 10.9 | |
| Cholesterol | (15) | rs6511720 | LDLR | 9.38E−08 | 0.01 | 0.432 | 1.2 | 12.3 |
| (5,7,15), (42)(AD), (43)(AD) | rs4420638 | APOE-C1-C2-C4 | 2.78E−06 | 0.01 | 0.370 | 1.0 | 19.1 | |
| LDL | (5,15) | rs6511720 | LDLR | 3.83E−06 | 0.01 | 0.776 | 1.6 | 12.3 |
| (5,7,15,42)(AD), (43)(AD) | rs4420638 | APOE-C1-C2-C4 | 8.72E−04 | 0.11 | 0.344 | 0.9 | 19.1 | |
| ApoB | (15)(LDL) | rs11591147 | PCSK9 | 6.43E−05 | 0.03 | 3.055 | 0.9 | 0.9 |
| (15)(LDL); (5)(LDL) | rs6511720 | LDLR | 1.23E−03 | 0.14 | 0.195 | 0.6 | 12.3 | |
| (15)(TG), (5)(TG), (6)(LDL), (17)(CRP) | rs780094 | GCKR | 3.21E−03 | 0.20 | 0.207 | 0.5 | 37.8 | |
| ApoAI | (15)(HDL) | rs1800588 | LIPC | 4.72E−05 | 0.03 | 0.332 | 1.0 | 20.5 |
| (15)(HDL, TG) | rs328 | LPL | 2.14E−03 | 0.19 | 0.575 | 0.5 | 10.3 | |
| CRP | (7)(LDL), (15)(LDL), (5)(LDL), (42)(AD), (43)(AD) | rs4420638 | APOE-C1-C2-C4 | 2.20E−07 | 0.01 | 0.404 | 1.4 | 19.1 |
| (17) | rs3091244 | CRP | 2.74E−04 | 0.05 | 0.182 | 0.7 | 5.5 | |
| Lp-PLA2 | (7)(LDL), (24)(LDL), (5)(LDL), (42)(AD) (43) (AD) | rs4420638 | APOE-C1-C2-C4 | 1.42E−06 | 0.01 | 0.490 | 1.48 | 19.1 |
| Homocysteine | (23)(CHD) | rs6922269 | MTHFR | 2.78E−05 | 0.03 | 0.375 | 1.5 | 31.1 |
| FVII | (15)(HDL, TG) | rs328 | LPL | 2.98E−04 | 0.04 | 0.102 | 0.0 | 10.3 |
The phenotype associated with the SNP from the GWAS, if different from the current study is given in brackets.
LDL, low density lipoprotein; TG, triglycerides; AD, Alzheimer's disease, CRP, C-reactive protein, HDL, high density lipoprotein.