Table 2.

Within-patients ANOVA differences in brain activation between the MPH and the placebo conditions during time discrimination versus order judgement. (BA, Brodman area; N voxels, number of voxels; Tal. co-ordinates, Talairach coordinates. p-value for ANCOVAs at p<0.05 for voxel activation and p<0.006 for cluster activation.)

brain region	BA	Tal. coordinates (x, y, z)	N voxels	cluster p-value
(a) methylphenidate>placebo
L orbitofrontal/inferior frontal gyri/insula	47/45	−33, −11, −2	419	0.002
R medial prefrontal gyrusa	46	40, 44, 9	38	0.02
L anterior cingulated gyrusa	32	−6, 37, 26	35	0.03
R lateral cerebelluma		14, −52, 46	30	0.05
(b) placebo>methylphenidate
R inferior/medial frontal gyri/insula	9/8/44	25, 15, 28	25	0.002
R superior frontal gyrus	8	18, 30, 49	14	0.003
R medial temporal lobe	22	29, −33, 7	23	0.002
R hippocampus, hippocampal gyrus	35	22, −15, −7	41	0.002
R putamen and globus pallidus	11	29, −11, 7	11	0.002

^aLarge three-dimensional clusters were broken into smaller two-dimensional clusters.