Table 4.
Tissue | Incidence/no. of animals necropsied (mean severity)a | ||||
---|---|---|---|---|---|
Males | |||||
Concentration (mg/L) | 0 | 14.3 | 28.6 | 85.7 | 257.4 |
Duodenum | |||||
Epithelium, hyperplasia | |||||
Focal | 0/50 | 0/50 | 0/50 | 1/50 (3.0) | 2/50 (3.5) |
Diffuse | 0/50 | 11/50** (2.0) | 18/50** (1.6) | 42/50** (2.1) | 32/50** (2.1) |
Females | |||||
Concentration (mg/L) | 0 | 14.3 | 57.3 | 172 | 516 |
Duodenum | |||||
Epithelium, hyperplasia | |||||
Focal | 0/50 | 0/50 | 1/50 (2.0) | 2/50 (3.0) | 0/50 |
Diffuse | 0/50 | 16/50** (1.6) | 35/50** (1.7) | 31/50** (1.6) | 42/50** (2.2) |
Jejunum | |||||
Epithelium, hyperplasia | |||||
Diffuse | 0/50 | 2/50 (2.0) | 1/50 (2.0) | 0/50 | 8/50** (1.9) |
Mean severity: 1, minimal; 2, mild; 3, moderate; 4, marked.
p ≤ 0.01 by poly-3 test.