Table 3.
Model predictions of daily NIS uptake of iodide into thyroid (μg/day) and total thyroid iodide stores (μg) for a 300-g adult rat, after 1 and 14 days of ClO4− exposure in drinking water at various doses.
| Dose (mg/kg/day)
|
||||||
|---|---|---|---|---|---|---|
| ClO4− exposure | 0 | 0.1 | 1 | 3 | 10 | 15 |
| 1 day | ||||||
| Average amount of iodide transported by NIS into thyroid (μg/day) | 38 | 28 | 10 | 4.6 | 1.7 | 1.2a |
| Total thyroid iodide stores (μg) | 17.0 | 17.0 | 16.9 | 16.8 | 16.0 | 14.9a |
| 14 days | ||||||
| Average amount of iodide transported by NIS into thyroid (μg/day) | 38 | 28 | 10 | 4.6 | 1.9 | 1.5 |
| Total thyroid iodide stores (μg) | 17.1 | 17.0 | 16.9 | 16.4 | 11.4 | 9.31 |
a
Model simulation for 2 days of exposure to 15 mg/kg/day. Data from Männistö et al. (1979).