Figure 4.
Effects of physiologic levels of E2 (10−9 M) combined with multiple concentrations of DDE or BPA measured by dopamine efflux assay. (A) E2 plus increasing concentrations of DDE during a 9-min dopamine efflux assay compared with E2-mediated dopamine efflux and DDE-mediated dopamine efflux. (B) E2 plus increasing concentrations of BPA during a 5-min dopamine efflux assay compared with E2-mediated dopamine efflux and BPA-mediated dopamine efflux. Values are means and SEs; numbers per treatment are as follows: E2, n = 18; BPA, n = 14; DDE, n = 14; DDE + E2, n = 15; BPA + E2, n = 15. Points above the zero point line indicate a positive efflux of dopamine from the cells.
*p < 0.05 compared with control for combinations. #p < 0.05 compared with E2 treatment. ##p < 0.05 compared with control for E2.