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. 2009 Apr 27;22(5):759–778. doi: 10.1021/tx9000489

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Copyright © 2009 American Chemical Society

This is an open-access article distributed under the ACS AuthorChoice Terms & Conditions. Any use of this article, must conform to the terms of that license which are available at http://pubs.acs.org.

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Model substrates for the γ-HO-PdG adduct in DNA. Top left: PdG (14), a model for the ring-closed form of γ-HO-PdG (2). Top right: PdG forms a Hoogsteen pair with dC in duplex DNA. Bottom left: Reduced γ-HO-PdG adduct (15), a model for the ring-opened N²-(3-oxopropyl)-dG (1). Bottom right: N²-(3-oxopropyl)-dG (1) forms a Watson−Crick pair with dC in duplex DNA.