Table 1. TDT results for the SNPs genotyped across MET.
| SNP ID | Position on 7qa (Mb) | Allele | Frequency | TR | NT | OR | (95% CI) | P-value |
|---|---|---|---|---|---|---|---|---|
| rs437 | 116084132 | C | 0.279 | 182 | 214 | 0.85 | (0.70, 1.04) | 0.107 |
| T | 0.721 | |||||||
| rs38833 | 116090787 | C | 0.840 | 1.00 | (0.59, 1.70) | 1.000 | ||
| T | 0.160 | 27 | 27 | |||||
| rs1858830 | 116099675 | C | 0.556 | 1.06 | (1.26, 0.67) | 0.555 | ||
| G | 0.444 | 261 | 246 | |||||
| rs40238 | 116101563 | A | 0.205 | 33 | 49 | 0.67 | (0.43, 1.05) | 0.070 |
| C | 0.795 | |||||||
| rs10271561 | 116102441 | C | 0.114 | 105 | 117 | 0.90 | (0.69, 1.17) | 0.363 |
| T | 0.886 | |||||||
| rs714180 | 116106238 | A | 0.492 | 258 | 290 | 0.89 | (0.75, 1.05) | 0.166 |
| G | 0.508 | |||||||
| rs38841 | 116107162 | A | 0.612 | 0.90 | (0.75, 1.08) | 0.233 | ||
| G | 0.388 | 219 | 244 | |||||
| rs38845 | 116109038 | A | 0.463 | 289 | 223 | 1.30 | (1.09, 1.54) | 0.0035 |
| G | 0.537 | |||||||
| rs9641562 | 116110027 | A | 0.942 | 0.83 | (0.56, 1.21) | 0.345 | ||
| C | 0.058 | 48 | 58 | |||||
| rs10487353 | 116111172 | G | 0.939 | 0.77 | (0.53, 1.13) | 0.209 | ||
| T | 0.061 | 48 | 62 | |||||
| rs38846 | 116111767 | C | 0.209 | 169 | 178 | 0.95 | (0.77, 1.17) | 0.656 |
| T | 0.790 | |||||||
| rs12535996 | 116112385 | A | 0.057 | 49 | 58 | 0.85 | (0.58, 1.24) | 0.401 |
| G | 0.943 | |||||||
| rs39748 | 116114666 | C | 0.543 | 0.93 | (0.63, 1.36) | 0.719 | ||
| G | 0.457 | 49 | 53 | |||||
| rs2299433 | 116118114 | C | 0.746 | 1.06 | (0.85, 1.33) | 0.634 | ||
| T | 0.254 | 155 | 146 | |||||
| rs38849 | 116119775 | C | 0.270 | 202 | 214 | 0.94 | (0.78, 1.14) | 0.589 |
| G | 0.730 | |||||||
| rs722134 | 116120945 | C | 0.126 | 34 | 27 | 1.26 | (0.76, 2.09) | 0.362 |
| T | 0.874 | |||||||
| rs38850 | 116124885 | A | 0.293 | 240 | 221 | 1.09 | (0.90, 1.30) | 0.374 |
| G | 0.707 | |||||||
| rs2237711 | 116125233 | A | 0.073 | 67 | 72 | 0.93 | (0.67, 1.30) | 0.686 |
| C | 0.927 | |||||||
| rs2237712 | 116125894 | A | 0.965 | 0.53 | (0.24, 1.13) | 0.117 | ||
| G | 0.035 | 10 | 19 | |||||
| rs11762213 | 116126518 | A | 0.067 | 57 | 64 | 0.89 | (0.62, 1.27) | 0.518 |
| G | 0.933 | |||||||
| rs35776110 | 116127333 | C | 0.997 | 0.33 | (0.03, 3.20) | 0.317 | ||
| T | 0.003 | 1 | 3 | |||||
| rs33917957 | 116127498 | A | 0.997 | 0.64 | (0.34, 1.20) | 0.150 | ||
| G | 0.003 | 16 | 25 | |||||
| rs2299436 | 116128619 | A | 0.787 | 1.28 | (0.83, 1.98) | 0.275 | ||
| G | 0.213 | 46 | 36 | |||||
| rs38854 | 116144447 | T | 0.448 | 52 | 53 | 0.98 | (0.67, 1.44) | 0.928 |
| C | 0.552 | |||||||
| rs38857 | 116152649 | C | 0.689 | 0.94 | (0.76, 1.17) | 0.626 | ||
| T | 0.311 | 158 | 168 | |||||
| rs38859 | 116166330 | C | 0.537 | 0.97 | (0.78, 1.19) | 0.757 | ||
| T | 0.463 | 173 | 179 | |||||
| rs10215153 | 116186367 | A | 0.321 | 217 | 236 | 0.92 | (0.76, 1.11) | 0.420 |
| G | 0.679 | |||||||
| rs2237717 | 116192623 | C | 0.557 | 0.95 | (0.66, 1.37) | 0.790 | ||
| T | 0.443 | 55 | 58 | |||||
| rs34589476 | 116199159 | C | 0.994 | 0.43 | (0.11, 1.66) | 0.157 | ||
| T | 0.006 | 3 | 7 | |||||
| rs2299440 | 116203563 | C | 0.816 | 1.17 | (0.90, 1.52) | 0.269 | ||
| T | 0.184 | 118 | 101 | |||||
| rs17526983 | 116203659 | A | 0.070 | 33 | 50 | 0.66 | (0.43, 1.02) | 0.062 |
| G | 0.930 | |||||||
| rs3807997 | 116207794 | C | 0.832 | 1.39 | (0.87, 2.20) | 0.174 | ||
| A | 0.168 | 43 | 31 | |||||
| rs2402118 | 116215809 | A | 0.360 | 263 | 248 | 1.06 | (0.89, 1.26) | 0.532 |
| C | 0.640 | |||||||
| rs193687 | 116219242 | C | 0.960 | 0.85 | (0.53, 1.35) | 0.485 | ||
| T | 0.040 | 33 | 39 | |||||
| rs41736 | 116223004 | C | 0.559 | 1.00 | (0.80, 1.24) | 1 | ||
| T | 0.441 | 160 | 160 |
Abbreviations: CI, confidence interval; NT, non-transmitted; OR, odds ratio; SNP, single nucleotide polymorphism; TDT, transmission disequilibrium test; TR, transmitted.
The position of the SNPs is according to the UCSC Genome Browser March 2006 Assembly.
Significant results are shown in bold.