Table 4. Case–control studies for the rs38845 variant in the United Kingdom and Italian populations.
| OR | OR | |||||||
|---|---|---|---|---|---|---|---|---|
| A vs G | AA/GA vs GG | |||||||
| Cases/controls | Cases n | Case Allele A (%) | Controls n | Control Allele A (%) | (95% CI) | P-value | (95% CI) | P-value |
| IMGSACa/ECACC | 333 | 0.522 | 185 | 0.478 | 1.19 | 0.189 | 1.35 | 0.164 |
| (0.92–1.54) | (0.89, 2.04) | |||||||
| Italian/Italian | 82 | 0.584 | 88 | 0.455 | 1.69 | 0.017 | 2.48 | 0.020 |
| (1.10–2.59) | (1.16, 5.33) |
Abbreviations: CI, confidence interval; IMGSAC, the International Molecular Genetic Study of Autism Consortium; OR, odds ratio.
a
There are a total of 666 probands, but there are 333 sib-pairs, so we generated 50 000 permutations of unrelated probands and the median (empirical 95% CI): (i) allele A frequency is 0.522 (0.500, 0.543) (ii) OR (A vs G) is 1.19 (1.09, 1.29) and (iii) OR (AA/GA vs GG) is 1.34 (1.16, 1.57).