TABLE 2.
D2-WT*
|
D2-V2.61(91)F
|
|||
---|---|---|---|---|
No NaCl | 140 mM NaCl | No NaCl | 140 mM NaCl | |
L-745,870 | 5232 ± 8419 (1) | 778 ± 89 (↓7) | 943 ± 328* (1) | 27.0 ± 4.34 (↓35) |
L-750,667 | >10,000 (1) | 1331 ± 927 (>↓7) | 1271 ± 924* (1) | 34 ± 24 (↓37) |
NGD 94-1 | >10,000 (1) | 3827 ± 3299 (>↓3) | >10,000* (1) | 616 ± 128* (>↓16) |
These are approximate values based upon extrapolation. The fold changes in affinity values relative to the receptor in the absence of sodium are shown in parentheses with the direction of the change indicated by arrows: ↓, decrease in Ki value corresponding to an increased affinity