Fig. 2.

Effect of TNFα inhibition on TVX/LPS-induced increases in plasma cytokines. Mice were treated with vehicles or with TVX/LPS in addition to etanercept or its vehicle as described under Materials and Methods. Mice were sacrificed 4.5 h after LPS administration. Plasma concentrations of IFNγ, IL-6, IL-10, IL-1β, MCP-1, and VEGF were measured as described under Materials and Methods. n = 4–6 animals/group. *, significantly different from respective Veh/Veh group. #, significantly different from TVX/LPS/Veh group.