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. 2008 Oct 8;328(1):69–82. doi: 10.1124/jpet.108.146068

Fig. 3.

Fig. 3.

Voltage dependence and agonist sensitivity of type IA currents in SRIs. A, left, sample recordings represent inward whole-cell currents induced by U-tube-applied choline at different membrane potentials. Right, plot of normalized type IA current peak amplitude versus membrane potential. Data are mean ± S.E.M. values from three neurons. In each neuron, the peak amplitude of type IA current at -88 mV was taken as 100% and used to normalize the amplitude recorded at various membrane potentials. B, left, sample recordings represent inward whole-cell currents induced by different concentrations of choline. Right, normalized peak amplitude of type IA currents is plotted against agonist concentration. The peak amplitude by 10 mM choline was taken as 100% in each neuron. Symbols and error bars represent mean and S.E.M., respectively, of results obtained from four SRIs. Solid line passing through the symbols represents the best fit of the data to a Hill equation.