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. 2008 Oct 23;328(1):116–122. doi: 10.1124/jpet.108.144600

Fig. 1.

Fig. 1.

Effect of FXR deficiency on body weight and lipid levels in LDLr-/- mice fed a high-fat diet. The LDLr-/- mice and LDLr-/-/FXR-/- mice were fed either a control (C) diet or an HF diet for 5 months. A, body weight was determined in LDLr-/- mice (solid lines) and LDLr-/-/FXR-/- mice (dashed lines) fed control diet (circles) or high-fat diet (triangles). Serum levels of phospholipids (B), free (C) and total (D) cholesterol, triglycerides (E), and bile acids (F) were determined. Data are expressed as mean (milligrams per deciliter) ± S.E.M. n = 6 mice per group. *, significantly different from same genotype fed the control diet. #, significantly different from LDLr-/- mice fed the same diet. P < 0.05.