Effect of FXR deficiency on body weight and lipid levels in
LDLr-/- mice fed a high-fat diet. The LDLr-/- mice and
LDLr-/-/FXR-/- mice were fed either a control (C) diet
or an HF diet for 5 months. A, body weight was determined in
LDLr-/- mice (solid lines) and LDLr-/-/FXR-/-
mice (dashed lines) fed control diet (circles) or high-fat diet (triangles).
Serum levels of phospholipids (B), free (C) and total (D) cholesterol,
triglycerides (E), and bile acids (F) were determined. Data are expressed as
mean (milligrams per deciliter) ± S.E.M. n = 6 mice per group.
*, significantly different from same genotype fed the control diet. #,
significantly different from LDLr-/- mice fed the same diet.
P < 0.05.