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Effect of FXR deficiency on ALT and ALP activity in LDLr-/- mice fed a high-fat diet. The LDLr-/- mice and LDLr-/-/FXR-/- mice were fed either a control (C) diet or an HF diet for 5 months. Serum levels of ALT (A) and ALP (B) were determined. Data are expressed as mean (units per liter) ± S.E.M. n = 6 mice per group. *, significantly different from same genotype fed the control diet. #, significantly different from LDLr-/- mice fed the same diet. P < 0.05.
