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. 2008 Oct 23;328(1):116–122. doi: 10.1124/jpet.108.144600

Fig. 4.

Fig. 4.

Effect of FXR-deficiency on expression of genes regulating lipid homeostasis and inflammation in LDLr-/- mice fed a high-fat diet. The LDLr-/- mice and LDLr-/-/FXR-/- mice were fed either a control (C) diet or an HF diet for 5 months. A, hepatic mRNA levels for genes in hepatic lipid homeostasis were determined by Northern blot analysis. B, hepatic levels of TNFα and ICAM-1 mRNA were determined by real-time Q-PCR. n = 6 mice per group. *, significantly different from same genotype fed control diet. #, significantly different from LDLr-/- mice fed the same diet. P < 0.05.