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Quantitative mRNA expression of desmin (A) and aB crystalline (B) in the patients’ repeated muscle biopsies before and 6 months after CAMPATH. There is a significant increase of desmin and reduction of αB-crystallin. A significant decline of mRNA expression of Mip-1α (CCL-3) was also noted (not shown); at the protein level, CXCL9 was reduced in some patients, as observed in double immunohistochemical staining for CXCL-9 and CD8 (C). *P < 0.05; **P < 0.01.
