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. 2009 Mar 6;136(7):1049–1061. doi: 10.1242/dev.014423

Fig. 4.

Fig. 4.

Transcriptional control of dendritic targeting in the Drosophila antennal lobe. (A) Schematic organization of the Drosophila antennal lobe (AL). For simplicity, only a subset of glomeruli are shown. Projection neurons (PNs) from anterodorsal (adPNs, red), lateral (lPNs, blue) and ventral (vPNs, green) lineages project dendrites to glomeruli where they connect with olfactory receptor neuron (ORN) axons (a vPN projection is not shown here). PN axons extend to higher-order olfactory centers in the brain. Transcription factors discussed in this review are shown. The schematic of glomerular organization is based on data from Couto et al. and is adapted with permission (Couto et al., 2005). (isl is also known as tup - Flybase.) (B-Cd) Cell-autonomous alterations in transcription factor expression redirect dendrite targeting. (B) Wild-type DL1 adPN (red) dendrites normally target to the DL1 glomerulus (shaded in red in the AL). adPNs express acj6 but not drifter or cut. (Ca-Cd) Dendrite targeting of genetically manipulated DL1 adPNs. (Ca) acj6 mutants extend dendrites outside their normal glomerulus. (Cb) acj6 mutant DL1 adPNs forced to express Drifter partially mistarget to more anterior glomeruli. (Cc) acj6 mutant DL1 adPNs forced to express Cut target medial adPN glomeruli. (Cd) Expression of both Drifter and Cut in acj6 mutant DL1 adPNs results in mistargeting of dendrites to medial lPN glomeruli. Schematic based on published data (Komiyama et al., 2003; Komiyama and Luo, 2007).