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. 2009 Feb 18;136(7):1071–1081. doi: 10.1242/dev.032912

Fig. 6.

Fig. 6.

Frzb-1 does not regulate Wnt/PCP or Bmp signaling. Frontal views, assayed at stage 40, from 2-3 independent experiments. Open primary mouth, black dotted line; closed stomodeum, yellow dotted; cg, cement gland. Black arrows indicate the primary mouth or region where it would form. Scale bars: 250 μm. (A) Schematic showing the prediction that if frzb-1 inhibits the PCP pathway, JNK inhibition would mimic frzb-1 overexpression. (B) Treatment with 1% DMSO results in a normal primary mouth (100%, n=15). (C) Treatment with 20 μm SP600125 results in neither a stomodeum nor a primary mouth (100%, n=15). (D) Schematic showing the prediction that if frzb-1 inhibits BMP signaling, increased Chordin would phenocopy frzb-1 overexpression. (E) The control GFP::HSE results in a normal primary mouth (100%, n=30). (F) GFP::HSE:chrd results in a small stomodeum (63%, n=32).