Fig. 2.

Tcf/β-catenin reporter transgene expression in wild-type and α3β1 integrin KO kidney papillae. All kidneys are from E17.5 mice. (A,D) Control WT mice without the Tcf-lacZ transgene, showing background staining in the cortex, but minimal staining in the papilla (P). (B,E)WT/Tcf-lacZ mice showing heavy lacZ staining in cortex and papilla. (C,F)KO/Tcf-lacZ mice showing background lacZ staining in the region from where the papilla would emerge, and decreased staining within the cortex. The results shown are representative of those obtained from three sets of kidneys.