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Influence of genotype on the penetrance of craniosynostosis
| Genotype | Number of mice with fused coronal suture |
|---|---|
| Wild type | 0/20 |
| EphA4+/− | 0/16 |
| Efna2−/− | 0/9 |
| EphA4+/−; Efna2+/− | 0/14 |
| EphA4−/− | 8/20* |
| EphA4−/−; Efna2+/− | 8/17* |
| Twist1+/− | 19/26 |
| Twist1+/−; EphA4+/− | 31/33 |
Fusion of the coronal suture was assessed at P21 in Alizarin Red S-stained whole-mount skulls.
No significant difference in penetrance was observed between EphA4−/− and EphA4−/−; EphA2+/− (P>0.05).
