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Examples of transcription factor-mediated reprogramming. Hierarchy of cell populations (blue shading) that appear during normal development and their relationship to each other (green lines). Dashed red lines illustrate examples of transcription factor-induced reprogramming. The bracketed cMyc gene indicates that this factor is dispensable for reprogramming. ICM, inner cell mass; ES, embryonic stem cell; iPS, induced pluripotent stem cell.
