Table 2. Biological functions identified by Ingenuity Pathway Analysis of significant differentially expressed genes (log2 ratio>±0.3) identified by SAM analysis (FDR = 13.5%).
| Category | Function Annotation | p-value* | Molecules |
| Endocrine System Development and Function | biosynthesis of androgen/steroidogenesis | 4.89E-05 | SCARB1, SRD5A1 |
| proliferation of pancreatic duct cells | 3.69E-03 | CXCR4 | |
| quantity of 4-androstene-3,17-dione | 1.29E-02 | SRD5A1 | |
| Small Molecule Biochemistry | endocytosis of cholesterol | 1.85E-03 | SCARB1 |
| breakdown of progesterone | 1.85E-03 | SRD5A1 | |
| biosynthesis of norepinephrine | 5.53E-03 | GATA3 | |
| synthesis of ganglioside GM3 | 7.37E-03 | CD9 | |
| uptake of taurocholic acid | 1.83E-02 | PRKCZ | |
| Nervous System Development and Function | morphology of neurons | 5.49E-04 | CD9, GATA3 |
| morphology of Purkinje cells | 1.85E-03 | ATP2B2 | |
| morphology of serotonergic neurons | 1.85E-03 | GATA3 | |
| fusion of vagus cranial nerve ganglion | 1.85E-03 | LMO4 | |
| polarization of astrocytes | 1.85E-03 | PRKCZ | |
| development of cerebellum | 1.98E-03 | ATP2B2, CXCR4 | |
| branching of sympathetic neuron | 3.69E-03 | LIFR | |
| differentiation/quantity of central nervous system cells | 5.43E-03 | ATP2B2, LIFR | |
| morphology of central nervous system | 5.53E-03 | ATRN | |
| development of Purkinje cells | 1.10E-02 | CXCR4 | |
| migration of motor neurons | 1.83E-02 | GATA3 | |
| biogenesis of synapse | 2.74E-02 | ATP2B2 | |
| guidance of motor axons | 2.74E-02 | CXCR4 |
*
Significance calculated for each function is an indicator of the likelihood of that function being associated with the dataset by random chance. The range of p-values was calculated using the right-tailed Fisher's Exact Test, which compares the number of user-specified genes to the total number of occurrences of these genes in the respective functional/pathway annotations stored in the Ingenuity Pathways Knowledge Base.