Table 1.

Parameters used in the population pharmacokinetic–pharmacodynamic (PK–PD) analysis for rabeprazole *

Base PK model	Final PK model

Base PD model	Final PD model

^*V_d, volume of distribution; CL, clearance; k_a, absorption constant; A_lag, absorption lagged time; E_m, maximal effect; E₀, baseline effect; EC₅₀, concentration when half E_m achieved; k_eo, elimination constant for the effect compartment; BSA, body surface area; γ, slope; GT, CYP2C19 genotype; θ_x, population mean of parameter x; η_x, intersubject variability of parameter x.