Table 2.
Risk factors for amiodarone toxicity
| Amiodarone toxicity | ||||
|---|---|---|---|---|
| No | Yes | Logistic regression * | ||
| Risk factors | Mean ± SD | Mean ± SD | OR (95% CI) | P |
| Cumulated time, years | 1.29 ± 1.1 | 6.02 ± 4.5 | 2.5 (1.1, 5.5) | 0.02 |
| Cumulated amiodarone dose,g | 80.2 ± 59 | 421 ± 336 | – | – |
| Cumulated amiodarone dose, g kg−1 body weight | 1.4 ± 1.2 | 6.1 ± 4.8 | 1.8 (1.06, 3.1) | 0.03 |
| Maintenance amiodarone dose, mg day−1 | 179 ± 35 | 160 ± 49 | – | – |
| Maintenance amiodarone dose, mg day−1 kg−1 body weight | 2.9 ± 1.1 | 2.4 ± 0.9 | 0.5 (0.2, 1.3) | 0.15 |
| Plasma concentration, amiodarone, mg l−1 | 0.84 ± 0.5 | 0.73 ± 0.6 | 0.6 (0.1, 3.1) | 0.59 |
| Plasma concentration, N-desethyl-amiodarone, mg l−1 | 1.03 ± 0.7 | 0.87 ± 0.7 | 0.7 (0.2, 2.3) | 0.53 |
| Fat tissue concentration, amiodarone, mg kg−1 | 41 ± 41 | 47 ± 40 | 1.01 (0.9, 1.02) | 0.69 |
| Fat tissue concentration, N-desethyl-amiodarone, mg kg−1 | 2.9 ± 4.7 | 3.2 ± 3.4 | 1.01 (0.8, 1.2) | 0.83 |
| Age, years | 73.2 ± 16 | 78.9 ± 11 | 1.03 (0.9, 1.1) | 0.29 |
| Body mass index | 23.1 ± 4.7 | 24.7 ± 4.2 | 1.1 (0.9, 1.3) | 0.36 |
*
Univariate analysis, OR given for each increase in 1 unit of the variable analysed. 95% CI, 95% confidence interval; OR, odds ratio; SD, standard deviation.