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. Author manuscript; available in PMC: 2009 May 26.
Published in final edited form as: Nat Med. 2005 May 8;11(6):678–682. doi: 10.1038/nm1247

Figure 3.

Figure 3

Quantum dot–loaded beads as drug delivery vehicle. Both 100 and 500 nm silica microspheres were loaded with QD470 and QD590, respectively, and administered to a VEGF-GFP mouse bearing a MCaIV tumor explant in a skinfold chamber. (a) After a 5-h period, a depth projection of five images taken at 5-μm intervals showed a heterogeneous extravasation pattern. (b) This image was meshed with a 20 × 20 grid, and regions that correspond to a maximum extravasated particle size of 500 nm and 100 nm are indicated with red and blue grids, respectively. In this fashion, we assessed the ability of candidates to access VEGF-GFP perivascular cells. The image is 707 μm across.