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. 2009 Jun 3;4(6):e5777. doi: 10.1371/journal.pone.0005777

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Reduced basal ATP level in Pink1 ^−/− dissociated cells (A), reduction of basal mitochondrial membrane potential Δψm in (B) dissociated cells and in (C) isolated mitochondria from Pink1 ^−/− versus wildtype brain, as well as reduction of respiratory activities for complexes I+III+IV (Cx I) and IV (Cx IV) (D,E) substantiate a mitochondrial dysfunction at old age.