Figure 6. Direct antimicrobial activity of DEFB4 and cathelicidin peptides.

M. tuberculosis H37Ra were incubated with a control peptide, DEFB4 peptide or cathelicidin peptide at 0.01 µg/ml, 0.1 µg/ml, 1 µg/ml and 10 µg/ml as well as media for three days. Bacterial proliferation was assayed using ³H-uracil up take. Data shown is (A) representative of three independent experiments, and (B) mean antimicrobial activity±SEM (n≥5). * = p≤0.05, ** = p≤0.01, *** = p≤0.001.