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. 2009 Jun 4;4(6):e5799. doi: 10.1371/journal.pone.0005799

Figure 1. ChIP-chip indicates strong N-Myc binding of the lif promoter in human neuroblastoma.

Figure 1

ChIP-chip data from previous study [29] was analyzed specifically for lif binding by N-myc. Several strong peaks were observed (brown). The lif promoter is greatly enriched in E-boxes including one canonical myc E-box CACGTG shown in purple and 6 non-canonical indicated by downward vertical arrows and listed in tabular form on the bottom left side. The 3 horizontal black bars labeled “a, b, and c” represent the locations of the 3 PCR products from ChIP PCR reactions in Fig. 4.The genomic locations are listed next to the E-boxes and refer to the last 4 digits of the location, with all being in the 28,970,000 base-pair range on chromosome 22.