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. 2009 Mar 17;113(21):5134–5143. doi: 10.1182/blood-2008-11-190769

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© 2009 by The American Society of Hematology

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Low-dose cortisol and epinephrine infusions to mimic nadir-to-peak concentration difference in circadian rhythm. Mean (± SEM) plasma concentrations of (A) cortisol, (B) epinephrine, and (C) norepinephrine in healthy men before (21:00 h), during (15, 30 minutes), and after (60, 90, 120, 180, 240, and 300 minutes) 30-minute infusions () of placebo (sodium chloride, ○), cortisol (8 μg/kg per minute, ●) and epinephrine (0.005 μg/kg per minute, ); n = 10. * P < .05, ** P < .01, *** P < .001, pairwise comparisons between cortisol/placebo (A) and epinephrine/placebo conditions (B) at single time points.

Inline graphic — Low-dose cortisol and epinephrine infusions to mimic nadir-to-peak concentration difference in circadian rhythm. Mean (± SEM) plasma concentrations of (A) cortisol, (B) epinephrine, and (C) norepinephrine in healthy men before (21:00 h), during (15, 30 minutes), and after (60, 90, 120, 180, 240, and 300 minutes) 30-minute infusions () of placebo (sodium chloride, ○), cortisol (8 μg/kg per minute, ●) and epinephrine (0.005 μg/kg per minute, ); n = 10. * P < .05, ** P < .01, *** P < .001, pairwise comparisons between cortisol/placebo (A) and epinephrine/placebo conditions (B) at single time points.