Table 1.
Cosinor data for circulating T cell subsets and hormone concentrations
| Mesor | Amplitude | Acrophase | Significance | |
|---|---|---|---|---|
| CD3+ T cells/μL | 1902.08 ± 85.00 | 387.91 ± 38.10 | 02:10 h ± 20 min | < .01 |
| CD4+ T-helper cells/μL | 1120.42 ± 70.29 | 243.99 ± 25.4 | 02:17 h ± 22 min | < .01 |
| Naive/μL | 510.20 ± 43.13 | 131.65 ± 16.00 | 02:41 h ± 23 min | < .01 |
| Central memory/μL | 349.87 ± 18.15 | 74.58 ± 6.60 | 02:02 h ± 20 min | < .01 |
| Effector memory/μL | 221.36 ± 15.40 | 42.31 ± 5.20 | 01:31 h ± 23 min | < .01 |
| Effector/μL | — | — | — | NS |
| CD8+ cytotoxic T cells/μL | 658.71 ± 30.08 | 140.01 ± 13.80 | 02:03 h ± 19 min | < .01 |
| Naive/μL | 326.49 ± 22.27 | 96.22 ± 9.90 | 02:09 h ± 20 min | < .01 |
| Central memory/μL | 86.52 ± 6.76 | 15.33 ± 2.00 | 02:16 h ± 26 min | < .01 |
| Effector memory/μL | 188.87 ± 12.37 | 24.72 ± 4.50 | 01:56 h ± 29 min | < .01 |
| Effector/μL | 66.69 ± 11.64 | 6.96 ± 3.4 | 15:34 h ± 116 min | < .05 |
| Cortisol, μg/dL | 7.68 ± 0.22 | 4.64 ± 0.20 | 10:40 h ± 19 min | < .01 |
| Epinephrine, pg/mL | 25.55 ± 3.03 | 6.69 ± 1.70 | 16:10 h ± 54 min | < .01 |
| Norepinephrine, pg/mL | 239.28 ± 17.18 | 71.41 ± 10.80 | 14:05 h ± 16 min | < .01 |
T cell counts and hormone concentrations were collapsed across conditions of a regular sleep-wake cycle and 24-hour continuous wakefulness and analyzed by the cosinor method. SEM values are presented as minutes.
Mesor indicates average value during a 24-hour period; Amplitude, difference between estimated maximum/minimum and Mesor (peak/nadir values can be calculated by adding the amplitude to/subtracting the amplitude from Mesor values, respectively); Acrophase, time of day of the maximum; Significance, P value of the zero amplitude test; and —, not applicable.