Figure 6. Pax6-regulated transcriptional networks in neocortical stem cells.

Pax6 directly regulates sets of genes that control four major processes in cortical neurogenesis: stem cell maintenance/self-renewal, neurogenesis, production of basal progenitor cells and cortical identity (black lines). These direct programmes are underpinned by indirect control of larger numbers of genes involved in each of these processes, as shown by the grey lines. Hes1 suppresses neurogenesis when continuously over-expressed in cortical stem/progenitor cells [51] and that is associated with repression (blue lines) of many of the same genes positively regulated by Pax6, including those genes required for genesis of basal progenitor cells.