Table 1.

Advantages of ACE inhibitor/diuretic combination therapy

Improved blood pressure control

Counterbalances renin-angiotensin system activation secondary to diuretic therapy

Reduced risk of electrolyte disorders (eg, hyper- or hypokalemia, hypomagnesemia)

Synergistic antiproteinuric effects, particularly in the presence of high sodium intake

Better therapeutic response in African-American patients

Blunts the adverse metabolic effects induced by the diuretic