Table 2.

Advantages of ACE inhibitor-calcium channel blocker combination therapy

Improved blood pressure control

Favorable metabolic effects

Counterbalances the reflex increase in sympathetic nervous activity induced by calcium channel blockers

Reduced vasodilatory edema

Diuretic and natriuretic effects of calcium channel blockers

Synergistic reduction of proteinuria and the rate of decline in glomerular filtration rate

Increased NO production and decreased cytokine production

Improved fybrinolitic balance

Improved arterial distensibility