Table 2.

Effect of flow rate and inner diameter of M1 at 0 °C.^a

flow rate of 1/THF (mL/min)	flow rate of n-BuLi/hexane (mL/min)	inner diameter of M1 (μm)	1 conversion (%)b	2 yield (%)b	3 yield (%)b
6.00	1.20	250	97	88	3
3.00	0.600	250	90	80	7
1.50	0.300	250	76	57	15
0.600	0.120	250	69	41	19
6.00	1.20	500	93	77	7
6.00	1.20	800	79	62	9

^aR1: ø = 500 μm, l = 3.5 cm, flow rate of methanol: 3.00 ml·min⁻¹. ^b Determined by GC.