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. 2009 Apr 29;5:16. doi: 10.3762/bjoc.5.16

Table 3.

Br-Li exchange reaction of 2,2′-dibromobiphenyl (1) followed by reaction with an electrophile using the microflow system.a

electrophile yield (%)c
monosubstituted product major byproduct
MeIb Inline graphic
5 		Inline graphic
6
89 Trace
Me3SiClb Inline graphic
7 		Inline graphic
8
80 3
PhCHO Inline graphic
9 		Inline graphic
10
90 Trace
PhCOPh Inline graphic
11 		Inline graphic
12
93 2

aFlow rate of a solution of 1: 6.00 ml·min−1, flow rate of n-BuLi/hexane: 1.20 ml·min−1, R1: ø = 500 μm, l = 3.5 cm (tR = 0.057 s). The conversion was higher than 95% in all cases. b R2: ø = 1000 μm, l = 200 cm, flow rate of a solution of an electrophile: 4.00 ml·min−1. cDetermined by GC.