Skip to main content
. 2009 Apr 29;5:16. doi: 10.3762/bjoc.5.16

Table 6.

Br-Li exchange reaction of 4,4′-dibromobiphenyl (17) followed by the reaction with an electrophile using the microflow system.a

electrophile yield (%)
monosubstituted product disubstituted product
MeIb Inline graphic
20 		Inline graphic
21
85 c 4 c
PhCHO Inline graphic
22 		Inline graphic
23
83 d 6 d
PhCOPh Inline graphic
24 		Inline graphic
25
84 d 5 d

a Flow rate of a solution of 17: 6.00 mL·min−1, flow rate of n-BuLi/hexane: 1.20 mL·min, R1: ø = 500 μm, l = 3.5 cm (tR = 0.057 s). b R2: ø = 1000 μm, l = 200 cm, flow rate of a solution of an electrophile: 4.00 mL·min−1. cDetermined by GC. dIsolated yield.