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. 2009 Mar-Apr;2(2):107–109. doi: 10.4161/cib.7713

Figure 1.

Figure 1

Communication of LCVs with endosomal and secretory trafficking pathways. LCVs are decorated with endosomal and secretory markers, which might be acquired by (i) direct fusion with cell organelles, (ii) interaction with transport vesicles shuttling between compartments, or (iii) recruitment from the cytoplasm. L. pneumophila produces two distinct classes of Icm/Dot-translocated effector proteins, which interact with PtdIns(4)P (SidC, SidM)5,18,35 or PtdIns(3)P (LpnE, LidA),15,35 respectively.