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Schematic depiction of the structure of the fusion proteins that were investigated for nuclear export. NESs (open boxes) of the HIV-1 Rev, HIV-1 RevM10, HTLV-I Rex, and PKI proteins, respectively, were fused via a flexible linker consisting of two glycine residues to the carboxyl terminus of GST (solid boxes). The amino acid position of the NESs within the respective proteins is indicated to the right. RevM10 is an export-deficient NES mutant (L78D and E79L) (11, 32).
