Abstract
Clinical isolates of Mycobacterium tuberculosis were used to compare various concentrations of streptomycin and ethambutol in the BACTEC 460 (Johnston Laboratories, Inc., Towson, Md.) radiometric method for drug susceptibility testing with those in the conventional method. Streptomycin used at 2.0 micrograms/ml for both methods showed a 0.99 agreement with susceptible strains and a 0.97 agreement with resistant strains. Ethambutol used at 2.5 micrograms/ml for the radiometric method showed 1.00 agreement with both susceptible and resistant strains when compared with ethambutol at 5.0 micrograms/ml for the conventional method.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- CANETTI G., FROMAN S., GROSSET J., HAUDUROY P., LANGEROVA M., MAHLER H. T., MEISSNER G., MITCHISON D. A., SULA L. MYCOBACTERIA: LABORATORY METHODS FOR TESTING DRUG SENSITIVITY AND RESISTANCE. Bull World Health Organ. 1963;29:565–578. [PMC free article] [PubMed] [Google Scholar]
- Fadda G., Roe S. L. Recovery and susceptibility testing of Mycobacterium tuberculosis from extrapulmonary specimens by the BACTEC radiometric method. J Clin Microbiol. 1984 May;19(5):720–721. doi: 10.1128/jcm.19.5.720-721.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Laszlo A., Gill P., Handzel V., Hodgkin M. M., Helbecque D. M. Conventional and radiometric drug susceptibility testing of Mycobacterium tuberculosis complex. J Clin Microbiol. 1983 Dec;18(6):1335–1339. doi: 10.1128/jcm.18.6.1335-1339.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Middlebrook G., Reggiardo Z., Tigertt W. D. Automatable radiometric detection of growth of Mycobacterium tuberculosis in selective media. Am Rev Respir Dis. 1977 Jun;115(6):1066–1069. doi: 10.1164/arrd.1977.115.6.1066. [DOI] [PubMed] [Google Scholar]
- Roberts G. D., Goodman N. L., Heifets L., Larsh H. W., Lindner T. H., McClatchy J. K., McGinnis M. R., Siddiqi S. H., Wright P. Evaluation of the BACTEC radiometric method for recovery of mycobacteria and drug susceptibility testing of Mycobacterium tuberculosis from acid-fast smear-positive specimens. J Clin Microbiol. 1983 Sep;18(3):689–696. doi: 10.1128/jcm.18.3.689-696.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Siddiqi S. H., Libonati J. P., Middlebrook G. Evaluation of rapid radiometric method for drug susceptibility testing of Mycobacterium tuberculosis. J Clin Microbiol. 1981 May;13(5):908–912. doi: 10.1128/jcm.13.5.908-912.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Snider D. E., Jr, Good R. C., Kilburn J. O., Laskowski L. F., Jr, Lusk R. H., Marr J. J., Reggiardo Z., Middlebrook G. Rapid drug-susceptibility testing of Mycobacterium tuberculosis. Am Rev Respir Dis. 1981 Apr;123(4 Pt 1):402–406. doi: 10.1164/arrd.1981.123.4.402. [DOI] [PubMed] [Google Scholar]
- Vincké G., Yegers O., Vanachter H., Jenkins P. A., Butzler J. P. Rapid susceptibility testing of Mycobacterium tuberculosis by a radiometric technique. J Antimicrob Chemother. 1982 Oct;10(4):351–354. doi: 10.1093/jac/10.4.351. [DOI] [PubMed] [Google Scholar]