Table 1.
PPI datasets currently integrated in UniHI
| Dataset | Proteins | Interactions | Method | Reference | Database location |
|---|---|---|---|---|---|
| MDC-Y2H | 1703 | 3186 | Y2H screen | Stelzl et al. (8) | http://www.mdc-berlin.de/neuroprot |
| CCSB-Y2H | 1549 | 2754 | Y2H screen | Rual et al. (9) | vidal.dfci.harvard.edu (flat file only) |
| HPRD-BIN | 8788 | 32776 | Literature | Mishra et al. (10) | http://www.hprd.org |
| HPRD-COMP | 1969 | 8107 | Literature | Mishra et al. (10) | http://www.hprd.org |
| DIP | 1085 | 1397 | Literature | Salwinski et al. (11) | dip.doe-mbi.ucla.edu |
| BIOGRID | 7953 | 24624 | Literature | Breitkreutz et al. (7) | http://www.thebiogrid.org |
| INTACT | 7273 | 19404 | Literature | Kerrien et al. (6) | http://www.ebi.ac.uk/intact |
| BIND | 5286 | 7394 | Literature | Bader et al. (12) | http://www.bind.ca |
| REACTOME | 1554 | 37332 | Literature | Joshi-Tope et al. (13) | http://www.reactome.org |
| COCIT | 3737 | 6580 | Text mining | Ramani et al. (14) | Bioinformatics.icmb.utexas.edu/idserve/ |
| ORTHO | 6225 | 71466 | Orthology | Lehner and Fraser (15) | http://www.sanger.ac.uk/PostGenomics/signaltransduction/interactionmap |
| HOMOMINT | 4127 | 10174 | Orthology | Persico et al. (16) | mint.bio.uniroma2.it |
| OPHID | 4785 | 24991 | Orthology | Brown and Jurisica (17) | ophid.utoronto.ca |
Number of proteins and interactions in each dataset as well as construction approaches and references.