Table 4.
Common CRP haplotypes and association results for altered postoperative CRP levels adjusted for clinical covariates following coronary artery bypass graft surgery.
| Haplotypes | rs1800947 | rs3091244 | Haplotype Frequency | Coefficient‡ | P-value† |
| H1 | G | C | 0.56 | Reference | |
| H2 | G | T | 0.29 | 0.21* | 0.029 |
| H3 | G | A | 0.07 | -0.03 | 0.771 |
| H4 | C | C | 0.06 | -0.36* | 4.64 × 10-3 |
| H Other | -- | -- | 0.02 | -0.56 | 0.808 |
Results are shown for dominant genetic model. Major and minor alleles, and forward/bottom strand orientation according to NCBI hg version 36 for Caucasian populations. CRP SNPs in strong linkage disequilibrium are combined; therefore not all genotyped SNPs are represented. ‡Describes associated effect of each haplotype on postoperative CRP levels based on a Tobit regression model. †Taking into account posterior probabilities, the overall joint test for the haplotype block adjusted for clinical covariates and repeated measures for postoperative CRP was significant at P = 7.44 × 10-8. *The CC haplotype was significantly associated with decreased postoperative CRP levels at P = 4.64 × 10-3 whereas the GT haplotype was associated with increased postoperative CRP levels at P = 0.029.