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. 2009 May 5;2:70. doi: 10.1186/1756-0500-2-70

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Copyright © 2009 Yoshiji et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effect of losartan on the liver fibrosis development in the OLETF rats. (A): Microphotographs of the liver of CDAA-treated OLETF rats. (B): The fibrosis area was evaluated by an image-analyzer. Losartan (30 mg/kg/day) significantly suppressed the CDAA-induced liver fibrosis development in the OLETF rats. Noteworthy was the finding that this inhibitory effect was achieved even at a clinically comparable low dose. The data represent the mean ± SD (n = 5). *: Statistically significance between the indicated group (p < 0.01).