Table 2.
Odds Ratios (95% CI) for head and neck cancer according to the studied polymorphisms
| 283 Cases | 295 Controls | OR ° | OR° for oral cavity (52 cases) | OR° for oropharynx (18 cases) | OR° for hypopharynx (23 cases) | OR° for larynx (186 cases) | |
|---|---|---|---|---|---|---|---|
| N (%) | N (%) | (95% CI) | (95% CI) | (95% CI) | (95% CI) | (95% CI) | |
|
p53 intron 3 (rs1788332) |
|||||||
| WW | 191 (67.5) | 209 (70.8) | 1* | 1* | 1* | 1* | 1* |
| M carriers | 92 (32.5) | 86 (29.2) | 1.30 (0.81 – 2.10) | 1.46 (1.78 – 2.88) | 1.75 (0.61 – 5.00) | 0.55 (0.18 – 1.75) | 1.17 (0.69 – 1.98) |
|
p53exon4Arg72Pro (rs1042522) |
|||||||
| ArgArg | 175 (61.85) | 169 (57.3) | 1* | 1* | 1* | 1* | 1* |
| Pro carriers | 108 (38.2) | 126 (42.7) | 1.07 (0.68 – 1.67) | 1.02 (0.53 – 1.97) | 1.66 (0.59 – 4.62) | 0.87 (0.34 – 2.22) | 0.91 (0.55 – 1.49) |
|
p53 intron 6 (rs1625895) |
|||||||
| GG | 194 (68.5) | 192 (65.1) | 1* | 1* | 1* | 1* | 1* |
| C carriers | 89 (31.5) | 86 (34.9) | 0.99 (0.63 – 1.58) | 0.49 (0.23 – 1.05) | 1.28 (0.45 – 3.65) | 0.70 (0.26 – 1.91) | 1.00 (0.60 – 1.67) |
|
p73 exon 2 G4A (rs1801173/rs2273953) |
|||||||
| GC/GC | 187 (66.1) | 214 (72.5) | 1* | 1* | 1* | 1* | 1* |
| AT carriers | 96 (33.9) | 81 (27.5) | 1.51 (0.94 – 2.43) | 2.43 (1.23 – 4.81)§ | 1.99 (0.69 – 5.69) | 0.48 (0.13 – 1.71) | 1.46 (0.86 – 2.46) |
* Reference group
° OR adjusted for gender, alcohol, pack-years, physical activity and fruit and vegetables intake
§ This association (p-value = 0.01) didn't remain noteworthy after the FDR test correction because the statistically significant threshold was set at p-value = 0.0002.