Table 1.
Gains and losses of DNA segments larger than 0.5 Mb in 30 chromophobe RCCs and 42 ROs.
| Tumor | Chromosomal location | Size, Mb | G/L/HL* | Genes |
|---|---|---|---|---|
| chRCC | 1p36.21-q44 | 232.12 | L | |
| RO | 1p36.33-p36.21 | 14.6 | L | |
| chRCC | 1p22.1 | 0.71 | HL | MTF2, TMED5, NY-SAR-41, DR1, BCAR3 |
| RO | 1q42.2-q44 | 18.1 | L | |
| chRCC | 2q13 | 0.95 | HL | BENE, NPHP1, LIMS3, RABP2L1, BUB1 |
| chRCC | 2q22.3-q23.2 | 5.9 | HL | |
| RO | 3p14.3 | 1.10 | G | IL17RD, HESX1, APPL, FLJ44290, ARF4, SLMAP, FLNB |
| RO | 3q13.11 | 2.72 | L | ALCAM, CBLB |
| chRCC | 5p14.1 | 1.54 | G | CDH9 |
| RO | 5q21.3-q35.3 | 71.48 | G | |
| chRCC | 6p22.2-q27 | 145.86 | L | |
| RO | 6q13-q27 | 96.3 | L | |
| RO | 6q15 | 0.74 | G | GABRR2, UBE2J1, RRAGD, ANKRD6, MDN1, CASP8AP2, OX62, BACH2 |
| RO | 6q24.2-q24.3 | 0.69 | G | EPM2A, FBXO30, SHPRH |
| RO | 7q11.22-q11.23 | 5.65 | G | |
| RO | 7q11.22-q11.23 | 3.30 | G | |
| chRCC | 7q11.22-q11.23 | 0.92 | G | CALN1 |
| RO | 7q22.1 | 2.78 | G | |
| RO | 7q34 | 0.52 | G | TIF1, Loc136306, ATP6V0A4 |
| RO | 9p24.3-p23 | 31.65 | G | |
| RO | 9q22.1-q33.2 | 32.75 | L | |
| RO | 10p15.3-p11.1 | 38.92 | G | |
| chRCC | 10q11.22 | 0.63 | G | PPYR1, ANXA8 |
| RO | 10q11.23-q21.1 | 1.4 | L | |
| RO | 10q11.23-q21.1 | 10.2 | L | |
| chRCC | 10q11.23-q22.3 | 29.17 | HL | |
| RO | 10q21.1-q26.3 | 78.1 | L | |
| RO | 10q21.1-q26.3 | 78.1 | L | |
| RO | 10q22.3 | 1.71 | G | |
| RO | 11p15.2-p15.1 | 1.2 | L | SOX6 |
| RO | 11p15.5-p12 | 43.10 | L | |
| chRCC | 11p15.5-p12 | 37,64 | L | |
| RO | 11p11.2 | 0.52 | G | OR4X2, OR4X1, OR4S1, OR4C3, OR4A47 |
| RO | 11p11.2 | 0.40 | G | |
| RO | 11p11.2-p11.12 | 0.63 | G | |
| RO | 11q13.2 | 2.07 | G | |
| RO | 11q22.3-q23.1 | 2.18 | L | |
| chRCC | 12p13.33-p12.1 | 22.49 | L | |
| chRCC | 12p13.33-p12.1 | 24.61 | L | |
| RO | 12p13.33-p11.1 | 32.76 | G | |
| chRCC | 12p13.2-p11.21 | 20.49 | L | |
| chRCC | 12q13.13-q21.1 | 20.12 | G | |
| RO | 12q13.2-q24.33 | 79.05 | G | |
| RO | 14q31.3-q32.33 | 22,4 | L | |
| chRCC | 15q13.3 | 1.01 | G | CHRNA7, ARGHAP11A |
| RO | 16p13.3 | 1.57 | G | |
| chRCC | 17p13.3-q23.3 | 59.77 | L | |
| chRCC | 18q22.2-q23 | 10.32 | G | |
| RO | 20p13-p11.1 | 26.22 | G | |
| chRCC | 20q11.1-q11.22 | 4.30 | L | |
| chRCC | 20q13.2-q13.33 | 10.01 | L | |
| chRCC | 21q21.3-q22.11 | 0.59 | HL | CLDN17, CLDN8, Loc138818, KRTAP13-1, KRTAP19-1, KRTAP19-3 |
| chRCC | 22q11.1-q12.3 | 16.5 | L | |
| chRCC | Xp22.33-q22.3 | 105.26 | L | |
| RO | Xq13.3-q21.1 | 1.76 | G |
* G – gain, L – loss, HL – homozygous loss