Table 3.
Functional division of lactogenic differentiation-regulated genes
| A. Up-Regulated genes | |
|---|---|
| Prolactin Regulated | |
| NM_008843 | prolactin induced protein |
| NM_009972 | casein beta |
| Dexamethasone Regulated | |
| NM_011361 | serum/glucocorticoid regulated kinase |
| NM_010286 | glucocorticoid-induced leucine zipper |
| NM_010217 | CTGF/CCN2 |
| NM_010730.1 | annexin A1 |
| Milk production: including carbohydrate and lipid metabolism | |
| NM_019739.1 | Fox O1 |
| AF378830.1 | prostaglandin-endoperoxide synthase 2 |
| NM_013467 | alcohol dehydrogenase family 1, subfamily |
| NM_007607 | carbonic anhydrase 4 |
| NM_007621.1 | carbonyl reductase 2 |
| NM_009128.1 | stearoyl-Coenzyme A desaturase 2 |
| NM_025436.1 | sterol-C4-methyl oxidase-like |
| NM_145942.1 | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 |
| NM_008084.1 | glyceraldehyde-3-phosphate dehydrogenase |
| BC038392.1 | ATPase, H+ transporting, lysosomal |
| BC019207.1 | low density lipoprotein receptor |
| NM_019703.1 | phosphofructokinase, platelet |
| NM_134469.1 | farnesyl diphosphate synthetase |
| NM_013820.1 | hexokinase 2 |
| NM_010687.1 | like-glycosyltransferase |
| NM_009270.1 | squalene epoxidase |
| U12330.1 | sterol regulatory element binding factor |
| NM_028803.1 | glucan (1,4-alpha-), branching enzyme 1 |
| NM_007408.1 | adipose differentiation related protein |
| XM_131456.2 | solute carrier family 31, member 1 |
| NM_011400.1 | solute carrier family 2glucose transporter) |
| NM_008489 | lipopolysaccharide binding protein |
| Apoptosis | |
| NM_022032.1 | Perp, p53 apoptosis effector |
| NM_138578.1 | Bcl2-like |
| NM_026217.1 | autophagy 12-like |
| U05989.1 | Par-4 |
| NM_019745.1 | programmed cell death 10 |
| NM_013492.1 | clusterin |
| Cytoskeleton, extracellular matrix, membrane structure | |
| NM_146120.1 | gelsolin |
| NM_009071.1 | Rho-associated coiled-coil kinase 1 |
| XM_132485.1 | RAS-related C3 botulinum substrate |
| BC037116.1 | adducin 3 (gamma) |
| NM_013470.1 | annexin A3 |
| NM_011313.1 | S100 calcium binding protein A6 (calcyclin) |
| BC013248.1 | kinesin family member 5B |
| XM_130768.1 | laminin, alpha 5 |
| NM_130448.1 | protocadherin 18 |
| NM_007404.1 | ADAM-9 (meltrin gamma) |
| D67076.1 | ADAMTS-1 |
| NM_009263.1 | secreted phosphoprotein/ostepontin |
| NM_010217 | CTGF/CCN2 |
| NM_010728.1 | lysyl oxidase |
| NM_009983.2 | cathepsin D |
| NM_144554.1 | claudin 4 |
| BC038280.1 | caveolin, caveolae protein, 22 kDa |
| NM_016900. | caveolin 2 |
| Transcription Factors and regulators | |
| NM_011461 | Spi-C ETS transcription factor |
| XM_123496.1 | Tcfcp2-related transcriptional repressor 1 |
| NM_011803.1 | CPEBP |
| NM_057211.1 | Kruppel-like factor 9 |
| NM_019739.1 | Fox O1 |
| NM_010907.1 | inhibitor of NFkB |
| Growth Control and Signaling | |
| NM_007669.1 | cdk inhibitor 1A (P21) |
| NM_007635.1 | cyclin G2 |
| NM_008960.1 | phosphatase and tensin homolog |
| NM_010515.1 | insulin-like growth factor 2 receptor |
| NM_021099.2 | kit oncogene |
| NM_007918.1 | eukaryotic translation initiation factor 4E binding protein 1 |
| NM_009721 | ATPase, Na+/K+transporting, beta 1 poly |
| BC009155.1 | microsomal glutathione Stransferase 1 |
| NM_010884.1 | N-myc downstream regulated 1 |
| NM_019971.1 | PDGF, C polypeptide |
| NM_011057 | PDGF, B polypeptide |
| NM_012671.1 | transforming growth factor alpha |
| NM_011338 | small inducible cytokine A9 |
| NM_011944 | MAPKK |
| NM_012519.1 | calcium/calmodulin-dependent protein kinase II, delta |
| AF378830.1 | prostaglandin-endoperoxide synthase 2 |
| BC038069.1 | IGFBP5 |
| BC002092.1 | v-maf oncogene family, protein G |
The functional division of genes transcriptionally regulated in HC11 cells undergoing lactogenic differentiation. The list of genes that exhibit elevated expression in HC11 cells undergoing lactogenic differentiation are categorized in functional divisions. The list does not include all genes with 2-fold or greater increase and some genes are listed in more than one category