Fig. 1.

Sequence alignment of the CCN proteins. The sequences of the 6 human CCN proteins were aligned using the T-Coffee server (Notredame et al 2000). The start and finish points of each domain are indicated and various important regions on the molecules are highlighted. In the IGFBP domain the “thumb” and GCGCCxxC motif are shaded in red. In the VWC domain the integrin αvβ3 site is highlighted in yellow. In the TSP domain the α6β1 binding site is highlighted in blue. This region also contains the bioactive peptide section (Karagiannis and Popel 2007). The integrin α6β1 and HSPG binding sites and the possible reverse integrin GDR motif in the CT domain are all highlighted in green